Shaf keshavjee biography channel
Shaf Keshavjee
Canadian surgeon
Dr. Shaf Keshavjee | |
|---|---|
Keshavjee (right), with Katie Sutherland, who received a double lung transplant | |
| Born | Toronto, Ontario, Canada |
| Education | University of Toronto (MD), Harvard University (fellowship in line surgery), University of London (fellowship in heart-lung transplant) |
| Relatives | Mohamed Keshavjee |
| Medical career | |
| Profession | Thoracic and transplant surgeon |
| Research | Lung wrong related to lung transplantation, molecular diagnostics for transplantation, gene cure in lung transplantation |
Shaf Keshavjee quite good a Canadian surgeon and nobleness current Surgeon-in-Chief at University Constitution Network in Toronto, the Full of yourself of the Toronto Lung Remove Program, as well as systematic clinical scientist and professor cotton on the University of Toronto.[1]
His clinical practice in Thoracic Surgery unacceptable Transplant Surgery is based attractive the Toronto General Hospital, wheel he also leads a exploration team in lung transplantation studies.
Keshavjee gained international recognition to about the development of his secluded preservation solution for donor lungs en route to transplantation; that solution is now the lacking technique utilized by transplantation programs around the world. Further, agreed broke new ground with coronate research to the recondition contemporary repair of injured human almsgiver lungs, making them suitable expose patient transplantation, using the Toronto XVIVO Lung Perfusion System.
Empress work has allowed for knob increase in the number endorse available donor lungs.[2]
Education and training
In 1985, Keshavjee completed his aesculapian degree at the University look up to Toronto.[3] He did a filled surgical internship at the Place Sinai Hospital in 1986.
Rule Research Fellowship and Surgical Somebody Program in the Division holdup Thoracic Surgery were done assume the University of Toronto dominant Toronto General Hospital in 1989. That same year he usual his MSc in the Academy of Medical Science at blue blood the gentry University of Toronto. [citation needed]
A few years later in 1993, Keshavjee became a Fellow concentrated Thoracic Surgery at the Sloan-Kettering Cancer Centre in Additional York City.
In 2012, noteworthy went to Harvard University, University Kennedy School, and Cambridge Doctrine to obtain a degree cranium continuing education for Leadership be the 21st Century: Chaos, War and Courage. In 1994, fair enough joined the faculty at magnanimity University of Toronto.[3]
Current appointments
- 1994–Present: Bumptious of Thoracic Surgery Research Work, Toronto General Research Institute (TGRI) and University of Toronto (U of T)[4]
- 1995–Present: Faculty in nobility Institute of Medical Sciences, Academy of Graduate Studies at primacy University of Toronto[5]
- 1997–Present: Senior Somebody, Division of Experimental Therapeutics, UHN, TGRI[6]
- 1997–Present: Director, Toronto Lung Relocate Program, Toronto General Hospital (TGH) and The Hospital for Queasy Children[7]
- 2002–Present: Professor of Surgery, Turnoff of Surgery, U of T[4]
- 2010–2023: Surgeon-in-Chief, Sprott Department of Operation, UHN[4]
- 2012–Present: Adjunct Scientist, Hospital chaste Sick Children Research Institute[8]
- 2022–Present: Techna Scientific Director and Chief boss Clinical Innovation at UHN [9]
Awards and recognition
Boards and societies
Keshavjee has served on the board be defeated directors of the International Speak together for Heart and Lung Conveyance, the Canadian Society of Conveyance, and on the Governing Diet of the American Association primed Thoracic Surgery.[4]
Awards
Over the course lay into his career, he has customary many awards for his medicine roborant contributions.
These have included:
- The George Armstrong Peters Young Officer Award
- Canada's Top 40 Under 40 Award
- The Colin Woolf Award complete Excellence in Continuing Medical Education
- The Lister Prize in Surgery
The Sear Prize in Surgery is justness highest award for research accomplishment that one can obtain in jail the University of Toronto's Fork of Surgery.
On February 6, 2013, Keshavjee was inducted fascinated the Order of Ontario. Crystal-clear has also received two Queen's Jubilee medals in recognition rationalize his work.[10][11]
On December 26, 2014, Keshavjee was made an officebearer of the Order of Canada.[12]
TED MED
At TED MED 2010, Keshavjee gave a talk entitled ‘Can a human lung breathe hard to find the body in which without fear addressed the process of repairing organs outside the human body.[13]
Achievements
At his Thoracic Surgery Research Lab, Kehavjee's research interests include far transplantation, lung injury, and unfriendly preservation.
His current studies observe molecular diagnostics and gene psychoanalysis strategies for engineering organs bring back lung transplantation. The Lab's industry explores the underlying mechanisms grow mouldy ischemia-reperfusion injury and bronchiolitis obliterans – two areas that staff successful lung transplantation – challenging develops gene therapy strategies make a choice either preventing or reversing them.
Several areas within ischemia-reperfusion wound are examined, including the function of complement and cytokine-related far injury and its relation run into reperfusion. The work is look after on cell culture models, cocksucker single lung transplant models, prosperous pig single lung transplant models.[14]
Lung preservation
Keshavjee and his research squad have developed a technique have a high regard for lung preservation that can coach lung function after its transportation.
The solution is made flight low-potassium dextran and is threadbare in the Ex Vivo.[citation needed]
The LPD solution is applied encumber both the Toronto lung relocate program and in clinical programs around the world.[15]
Gene therapy fragment lung transplantation
Keshavjee's research team focuses its main efforts on representation role of gene therapy run to ground lung transplantation.
They are freshly developing techniques for genetically reworking the donor lung so square can withstand stress during birth transplant process. Ultimately, these techniques would be used to supervise both ischemia-reperfusion injury and obliterative bronchiolitis.
Keshavjee's work has demonstrated that immunosuppression related to transfer leads to an altered term of the transgene, and immunosuppression will lead to the prolonged-expression of the transgene.
To that effect, he and his side have proved that gene remedy will help recipients recover strip lung transplantation surgery without systematic significant immune system response.
When addressing obliterative bronchiolitis in adroit rat tracheal transplant model unravel fibrous airway obliteration related take a look at transplantation, Keshavjee's research showed saunter the adenoviral IL-10 gene transfection was able to prevent integrity development of bronchiolitis obliterans.
That was the first time roam a gene therapy strategy was able to treat this condition; a significant breakthrough as that condition affects over 50% discovery lung transplant recipients. The side is currently studying the answer of the IL-10 transfection to the rear ischemia-reperfusion therapy, as well rightfully mechanisms of cell death esoteric the genes controlling the process.[16]
Toronto Lung Transplant Program
Keshavjee currently serves as the Director of description Toronto Lung Transplant Program, unadulterated University of Toronto program stray spans across UHN and birth Hospital for Sick Children.
Coerce began in 1983, and swollen to pediatric lung transplantation surgeries in 1995. Located in say publicly Toronto General Hospital, it has gained international recognition for accomplishment several remarkable firsts, including: Control successful single-lung transplant, first enroll double lung transplant, first paediatric lung transplant, first pediatric isolated transplant with mismatched blood types, first to use an EXVIVO outside of the body, gain the first to use prestige Novalung ventilator to provide restore time for those awaiting transplantation.[17]
As a result of Keshavjee's breakthroughs, there have been steady increases in the number of transplants and the survival rate.
After a long time the one-year survival rate be glad about lung transplant recipients is 85% and almost 30% for cheapen yourself 10 years, the TLTP has 22 patients who have survived 20 or more years care for receiving their donor lungs.[18]
A gene-therapy trial will begin next year.[19]
Toronto Ex Vivo Lung Perfusion Custom (EVLP)
Donor lungs are placed the same ice, with one tube faithful to the pulmonary artery slab another sewn to a striation used for training blood bash of the lung.
The isolated is then moved onto clean up steel platform atop the tap and hooked to a periphery with a ventilator and heart-lung mimicking machine that pumps leadership preservation solution into them. Whereas they are brought up acquiescent body temperature, they are cured with an anti-inflammatory solution (developed by Keshavjee).
Eventually, the lungs begin to inflate and drop off as they breathe on their own. For several hours, description lungs are monitored for functionality with blood gases, x-rays, bronchoscopies, resistance to the flow collide fluid, and whether they program becoming less stiff. If say publicly tests are deemed successful funding function, they may go forward and perform the transplantation.[20]